Kazakh Scientist Calls for National Brain Biobank to Advance Neurodegenerative Disease Research
Brain biobanks have revolutionized the study of neurodegenerative diseases, shedding light on their causes and consequences. Kazakh clinician-scientist Rauan Kaiyrzhanov, in an interview with The Astana Times, discussed the research impact of brain biobanks and shared his perspective on the idea of establishing a brain biobank in Kazakhstan.
Kaiyrzhanov, a pioneer in Kazakh-British collaboration in neurogenetics, initiated his research in 2015 at the University College London (UCL). He has been gathering DNA samples from patients with rare neurological disorders at the National Center of Neurosurgery in Astana for genetic analysis in London. His team has collected DNA samples from over 3,000 families with rare early-onset neurological diseases and from patients with Parkinson’s and Alzheimer’s diseases in Central Asia and Transcaucasia since 2017.
Neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases, affect millions globally, with a higher incidence in more developed countries due to age and industrialization. Kaiyrzhanov highlighted that these diseases often result from genetic predisposition influenced by various genes and environmental factors.
Biobanks play a crucial role in storing and managing DNA samples for research purposes. While Kazakhstan has biobanks in universities, the lack of a centralized network hinders their efficiency. Kaiyrzhanov emphasized the importance of qualified specialists and state support in establishing a national biobank.
The process of brain sample collection is complex, involving the preservation and management of post-mortem brain tissue for research purposes. Collaboration between institutions in Kazakhstan and UCL has been fruitful, extending to other Central Asian countries.
Kaiyrzhanov stressed the significance of involving both patients with diseases and healthy individuals in sample donation to drive scientific breakthroughs. He underscored the need for patient and public involvement and engagement to build trust and awareness in medical research within the community.
In conclusion, the establishment of a brain biobank in Kazakhstan holds promise for advancing research on neurodegenerative diseases and improving diagnostic and treatment strategies. With the right support and collaboration, Kazakhstan can contribute significantly to the global fight against these debilitating conditions.
